Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels*
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چکیده
منابع مشابه
Molecular biology of adenosine triphosphate-sensitive potassium channels.
KATP channels are a newly defined class of potassium channels based on the physical association of an ABC protein, the sulfonylurea receptor, and a K+ inward rectifier subunit. The beta-cell KATP channel is composed of SUR1, the high-affinity sulfonylurea receptor with multiple TMDs and two NBFs, and KIR6.2, a weak inward rectifier, in a 1:1 stoichiometry. The pore of the channel is formed by K...
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Potassium Channels To the Editor: We read with interest the publication by Lee et al1 describing the potential mechanisms and effects of intracoronary conjugated estrogens on coronary vasomotion and myocardial ischemia in patients undergoing percutaneous coronary angioplasty. We were surprised at the very high bolus dose of intracoronary Premarin (Wyeth-Ayerst) given—5 mg into the left coronary...
متن کاملAdenosine triphosphate-sensitive potassium channels in the cardiovascular system
NICHOLS, C. G., AND W. J. LEDERER. Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Am. J. Physiol. 261 (Heart Circ. Physiol. 30): H1675-H1686, 1991.-ATP is normally available in cells at millimolar concentrations and is “buffered” by intracellular pools of other high-energy phosphates, such as creatine phosphate. Thus intracellular [ATP] ([ATPI;) may seem an un...
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Cardiomyopathies have been indicated to be one of the leading causes of heart failure. Though it was indicated that genetic defects, viral infection and trace element deficiency were among the causes of cardiomyopathy, the etiology has remained to be fully elucidated. Cardiomyocytes require large amounts of energy to maintain their normal biological functions. Adenosine triphosphate-sensitive p...
متن کاملNeuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels.
BACKGROUND Ischemic preconditioning is an important intrinsic mechanism for neuroprotection. Preconditioning can also be achieved by exposure of neurons to K+ channel-opening drugs that act on adenosine triphosphate-sensitive K+ (K(ATP)) channels. However, these agents do not readily cross the blood-brain barrier. Inhalational anesthetics which easily partition into brain have been shown to pre...
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ژورنال
عنوان ژورنال: Endocrine Reviews
سال: 1999
ISSN: 0163-769X,1945-7189
DOI: 10.1210/edrv.20.2.0361